As aired
Prakash opens the show (Monday, September 14) and brings on Zvi Mowshowitz as a drop-in guest for the full episode. Zvi jokes about being exhausted and about the mainstream media's rush to spin up the weekend's news. Nathan notes that ideas he had floated weeks earlier — like giving the frontier labs ninety days to coordinate among themselves before the government steps in — have suddenly moved much closer to the center of the public conversation, a shift he says he wasn't prepared for.
Prakash then gives a detailed recap of Dario Amodei's essay "We Must Pace the Frontier," published Friday evening: Dario's personal framing (his father's illness, and his own early-stage cancer, which wouldn't have been treatable fifty years ago), his two stated concerns — recursive self-improvement accelerating sharply since roughly the summer, and an OpenAI/Hugging Face agent-swarm incident he says could, within six to twelve months, enable a persistent botnet capable of hundreds of billions of dollars in internet-scale damage — and his three-step pacing plan: unilateral embedded third-party evaluators (such as METR), industry-wide coordination among democratic frontier labs, and eventual global coordination that includes authoritarian governments.
Zvi says he's in near-full, "violent" agreement with Dario on substance, despite narrower disagreements over implementation details like capability versus input thresholds, and calls the essay "about as good as we could have gotten." The discussion then turns to David Sacks's viral post arguing this is purely a product-liability matter that doesn't require antitrust waivers. Zvi strongly disputes that framing — noting the labs aren't seeking liability waivers at all, and are if anything asking for liability-establishing clauses — but credits Sacks's underlying point that Anthropic and OpenAI, as the frontier leaders, bear responsibility to pace themselves regardless of what competitors do, calling it more defensible than other critics' regulatory-capture or IPO-marketing theories.
Nathan Labenz opened a bio-risk detour, describing the last few weeks as increasingly unsettling: he said AI risk has moved from "could get scary" to "legitimately scary," pointing to OpenAI's report describing an early agent working with a protein database, and to AI's growing capacity for social engineering around real-world lab barriers. He asked Zvi Mowshowitz how alarmed Zvi is about bio risk specifically.
Zvi Mowshowitz said the "protein" detail was overblown but argued bio is now entering a "meta danger zone" — the point where it's unclear whether risk has crossed the threshold. He cited Anthropic's report on roughly five attempts to misuse Claude for bio-related purposes (mostly dual-use or legitimate-seeming requests, like help with a grant application) and warned that frontier internal models at Anthropic and OpenAI, if jailbroken or handed to bad actors, could meaningfully raise danger, given bio's fat-tailed, power-law risk profile.
Prakash Narayanan read at length from a widely shared rebuttal by David Bellamy — who says he's both trained a frontier LLM and synthesized custom viruses by hand — arguing that AI-generated viral genomes are not the bottleneck to bioweapons; physical synthesis infrastructure, equipment, and real-world iteration are, and no autonomous, fully API-driven synthesis lab of the kind needed even exists. Zvi pushed back hard, calling the argument absurd and reframing it as a classic defense-in-depth problem: even if no single step (like sequence screening) is individually a hard bottleneck, an AI that solves several of the roughly ten steps needed to make a dangerous virus — for instance, by helping design a near-variant of a known pathogen that evades scanners like those used by SecureBio — collapses the number of remaining barriers and makes the overall chain of defenses far more likely to fail.
Prakash argued that Dario's essay's catastrophic scenarios aren't impossible but require confronting the friction of the real world — financial systems, DNA-synthesis supply chains, and law-enforcement surveillance that scale up detection risk alongside any attempt to scale up illicit activity. He pushed back specifically on Gwern Branwen's scenario of an AI bootstrapping resources through cryptocurrency mining, arguing that the physical footprint (megawatt-scale power plants) and anti-money-laundering choke points above roughly a million dollars make anonymous scaling implausible, and cited examples like the Chinese crackdown on Cambodia-based pig-butchering scam networks and currency-control enforcement to argue that "ungoverned spaces" mostly don't exist anymore.
Zvi disagreed sharply, arguing Prakash's own examples actually illustrate how much goes unnoticed at scale — pointing to Hugging Face security incidents that went undetected for a month and to real-world cases of individuals obtaining dangerous pathogens by mail simply by claiming to do research. He argued a sufficiently capable AI doesn't need to succeed on its first attempt (a rejected request costs nothing, since nobody got hurt), can simply try again and again, and can route around financial choke points by co-opting willing human intermediaries — while state and non-state actors (North Korea, Russia, jihadist groups) already have the budgets and motive to do this kind of damage without needing an AI to talk anyone into it. The two briefly traded personal analogies, including Zvi's own experience getting caught scaling up a sports-betting operation, before both agreed they'd drifted far from the news itself.
Nathan then redirected the conversation, clarifying that his underlying concern isn't limited to digital or cyber risk but extends to physical-world harm, and endorsing Zvi's framing that the current moment is a "meta danger zone" — uncertainty about whether we're even in the real danger zone yet — as reason enough for serious concern, setting up further discussion of near-term probability.
Nathan asked Zvi to react to the capability signals coming out of the frontier labs — citing a post from former Cognitive Revolution guest Adam Majmudar and Dario Amodei's essay describing rapidly advancing internal capabilities, plus reports of Astra hitting a 10% solve rate on Millennium Prize problems versus a new internal model reportedly reaching 25-40% — and asked what the best and worst paths forward look like from here. Zvi argued that OpenAI and Anthropic are both effectively "screaming," through announcements like the "alien mind" framing and a Millennium Prize post that oddly didn't focus on the Millennium Prize, that their internal models are a generation or more ahead of anything public and progressing so fast that safety supervision and infrastructure can't keep pace — leaving each lab afraid that slowing down means falling permanently behind while pressing forward risks losing control entirely. He described the good outcome as OpenAI and Anthropic being permitted to cooperate — sharing insights, shifting investment into security and transparency, and reciprocating so neither feels at a competitive disadvantage — eventually formalizing into industry or international rules, while U.S. chip controls keep Chinese labs sufficiently behind despite what Zvi called black-hat efforts by every major Chinese lab (illicit accounts, evasion of regional controls, attempts to extract chain-of-thought) to distill off Anthropic's Opus models.
The conversation pivoted to IPO politics after Prakash noted that Sam Altman had just said OpenAI is postponing its IPO, and asked whether Dario and Anthropic should do the same. Zvi called it unfortunate that Anthropic is IPO'ing at all, noted the company would retain founder control via Zuckerberg-style supervoting shares, and said postponing into 2027 alongside OpenAI would be a very strong reciprocal signal of good faith — while acknowledging real costs, including that tens or hundreds of billions of dollars in donor-advised funds tied to AI-safety and other philanthropic causes can't be liquidated while Anthropic remains pre-IPO.
Prakash pressed a sincerity critique: that Anthropic warning about existential danger while pursuing an IPO that will enrich its founders and their friends looks bad regardless of actual motive, and could be seen as undermining its own AI-safety messaging. Zvi countered with a test — would doomsaying rhetoric actually help a company's stock price, government relations, or consumer trust right before pricing an IPO? He argued the answer is obviously no, so it can't be a rational marketing strategy, and pointed to OpenAI's actual IPO postponement as a costly signal that safety-focused observers read as genuine evidence of good faith, in contrast to skeptics like Gary Marcus who instead read the same move as evidence of failure.
Nathan opened by asking Zvi to weigh in on two opposing predictions about the upcoming Trump-Xi summit. Collin Hogue-Spears, a former AWS-China staffer who worked directly with Chinese regulators, had told Nathan he expects little from the summit because Beijing believes it, not Washington, has the domestic situation under control and would simply use any US pause to catch up. Anton Leicht, by contrast, had argued the US would be the one to balk at a deal, since AI is one of the only domains where the US still leads China and Washington won't want to give up its one remaining edge. Nathan then put Zvi in "the David Sacks chair" and asked what Trump's actual negotiating strategy should be.
Zvi first circled back to a domestic risk he'd flagged earlier: that AI safety could become a partisan wedge issue, with the press casting Trump and Mike Johnson's caution as Republican foot-dragging against Democratic urgency, locking in years of gridlock until Democrats win a trifecta. He argued the single best action anyone can take right now is preventing that polarization, since Trump and Johnson are actually trying to hold a middle line — protecting data centers and growth, projecting strength toward Xi, while still acknowledging the problem — and deserve reinforcement rather than partisan spin. Turning to negotiating strategy, Zvi laid out classic high-stakes-negotiation logic: never let the other side think you're desperate for a deal, and never rule one out either, since a good deal can only be win-win. He predicted the summit most likely produces a cheap "tier one" agreement (something like mutual commitments against bioweapons misuse), possibly a modest tier two, but nothing bigger — grand bargains need groundwork laid via track-two diplomacy well before a crisis forces a rushed one.
Playing adviser, Zvi said he'd tell Xi plainly that the US labs aren't bluffing: they're acting against their own commercial and national interests, which only makes sense if they genuinely believe the alternative is catastrophic, and the US will act unilaterally on safety if it has to. The ask of China, he said, isn't a formal treaty but each side "getting its own house in order" while the US works to convince Xi the risk is real — through concrete demonstrations rather than by showing off internal models. Prakash added that Chinese leadership, being dominated by hard-science engineers rather than software people, would likely find a physical demonstration (a room-temperature superconductor, for instance) more persuasive than any software claim — prompting Zvi to half-joke that mass-exposing every computer password in real time would be the kind of extreme proof that might actually move them.
Continuing from an earlier point about an AI company's exposed S3 bucket, Zvi Mowshowitz argued that people are generally bad at judging in advance what evidence would actually change their minds, using the COVID-19 pandemic as an example of how predictions about triggering events only make sense in hindsight. Prakash Narayanan countered that specific events — Tom Hanks and Donald Trump both getting COVID — did visibly trigger a shift in public behavior, so it isn't true that nothing can ever cascade; Zvi agreed such triggers are real but essentially unforecastable in advance.
Nathan Labenz then asked Zvi to spell out what a US-China 'grand bargain' on AI could actually look like, prefacing that it's not either of their base-case prediction. Zvi laid out a narrow ask of China: don't steal or leak frontier model weights, don't race to match or surpass the frontier closed labs, don't release openly dangerous cyber-capable weights to the public, and don't smuggle chips to evade export controls. In exchange, Zvi said the US would be giving up real ground — deliberately slowing its own frontier AI lead — with compliance verified by vetted, embedded Chinese evaluators inside US labs, modeled on standard intelligence-verification agreements, who could confirm pacing commitments without seeing the underlying algorithms.
Prakash pushed back on the trade's premise, noting China has historically let the US do the expensive early research and then commercialized behind it, and isn't visibly worried about AI safety itself — so why would it pay a real price for a US slowdown, and what else could the US offer instead? Zvi's answer was that no deal may actually be necessary: if China's real interest is distilling, cheapening, and diffusing existing AI rather than racing to build superintelligence first, both countries can simply act in their own self-interest with no bargain required. As Zvi put it, the actual obstacle isn't China itself but the domestic fear of 'losing to China.'
Prakash pressed Zvi on what the US could actually offer China in a deal, given that AI-safety monitoring isn't something Beijing would pay much for. Zvi worked through the logic in real time: if Xi's China doesn't care that a US shift toward AI safety investment would slow American progress, then Washington doesn't need a deal with China at all, since the "stag hunt" argument for restraint among the American labs depends on China being a credible defector. Either China values slower US progress enough to want a deal, or it doesn't and the US doesn't need one — Zvi argued the US comes out ahead either way, so long as Chinese labs aren't racing to build a fundamentally different, more dangerous kind of AI.
Prakash then turned to Dario Amodei's Face the Nation answer that he would hand Anthropic's technology over only "to the right combination of governments" — not the US government outright — arguing this puts Anthropic, not any elected government, in ultimate control, and could cost Dario badly with the Trump administration. Zvi pushed back that the question was a "gotcha": in his view Dario's real answer is that it isn't Dario's call whether the US government takes control of Anthropic, and he wouldn't defy Washington if it did. But Zvi also argued Dario — like Sam Altman, who made a near-identical concentration-of-power statement the night before — is threading between contradictory sacred values (democratic control, anti-concentration-of-power, and loss-of-control risk) that can't all be satisfied at once, especially once specifics are demanded: full democratization of superintelligence doesn't work for logistical reasons, and handing the only AIs that matter to any single government, including a "noble" Trump administration, creates its own tyranny risk (Zvi's hypothetical: what happens if the 2029 winner is AOC?).
Nathan then flagged a live example of the tension: a Department of War CTO post declaring "Americanism, not effective altruism — the US will be AI dominant." Zvi called the Department of War "openly gone rogue," saying it keeps making outlandish statements — including barring its own people from using Claude over what it frames as a supply-chain risk, even as the Houthis reportedly try to use Claude to develop missile technology — while Anthropic itself keeps saying it wants to slow down. Nathan closed the segment by pivoting to a closing question for Zvi: how will anyone actually know if pacing the frontier is working, given how easy it would be to fake with PR while doing the same thing anyway.
Nathan Labenz closed out the Zvi Mowshowitz segment with three questions: how will we know if the frontier is actually being "paced," what's being underappreciated in the current flurry of coverage, and what other small, pressure-point campaigns (like the letter itself) a small group might run — floating, as one example someone had pitched him online, a tongue-in-cheek campaign to nominate Trump for the Nobel Peace Prize contingent on a China deal. Zvi Mowshowitz answered that embedded evaluators are a good first step, but that verification ultimately comes down to holistic judgment against a counterfactual nobody can know for certain. He argued that even in hindsight it's genuinely unclear which past interventions — founding Anthropic, the existential-risk framing, the six-month pause letter — helped or hurt AI safety, and that the Pacing the Frontier letter succeeded partly because its language was "shovel-ready" at the right moment. He dismissed worrying about the reaction of fixed ideological "usual suspects" (his Scott Alexander "rock" analogy) and argued the real near-term work is filling in concrete detail: what rules, thresholds, and authority embedded investigators would actually have. He noted that today's evaluator ecosystem (METR, Redwood, Apollo, and similar groups) is too culturally close to the labs to be a complete check on its own and needs to be paired with outside-view assessors — comparable to car-safety inspectors or a judge who forces a dispute into legible terms.
Asked what's being missed, Zvi said the underappreciated story is the degree to which people inside the labs themselves are seeing dramatic model improvement and are alarmed by it — that this, not any external campaign, is what's actually driving the current moment. He said if the trend continues, a Christiano- or Yudkowsky-style hard takeoff within the next year is plausible, one that would retroactively make current debates look trivial. Nathan thanked Zvi for the conversation and he signed off.
Prakash Narayanan then pushed back on the hard-takeoff framing, arguing that whatever its merits, it doesn't hold up against the frame of reference the general public, administrations, and bureaucrats actually use. He read a passage from Ben Thompson arguing that Dario Amodei's essay is ultimately premised on AI cutting off physical, human-controlled infrastructure — the internet — and that a worldwide internet shutdown, while costly, is not the civilization-ending event it's sometimes treated as, citing society's recovery from COVID-era border closures and multi-trillion-dollar losses. Prakash argued Dario's essay may have backfired for two reasons: it gave critics a concrete, mockable scenario to attack as not that big a deal, and its call for coordinated action across governments was, in his view, close to the worst possible framing — one that risks putting Anthropic in opposition to multiple administrations and "poisoning the chalice" for other labs as well.
Prakash closed out the discussion by arguing that Dario's language about needing to move quickly — and specifically the idea of leaning on evaluators like METR as the arbiters of what's safe — was itself a red flag. American institutional change, he argued, is textual and deliberately slow: laws get written, lobbied, and digested through law schools and law reviews over decades, the way the delegitimization of slavery and segregation took a generation to work through the system, and even early leaders like John Adams and Thomas Jefferson fought over attempts to suspend civil rights in the name of emergency. Invoking urgency to bypass that democratic process, he said, is exactly the pattern the country has always pushed back against. He argued the labs have effectively "lost the country" by dismissing public and non-expert critics — pointing to commentators waving away figures like David Sacks, and to Dean Ball's "you didn't predict AI, so trust the experts" framing — instead of doing the harder work of persuading the public and the "elites" (per Robin Hanson's experts-vs-elites distinction) who actually hold the levers of political power.
Nathan agreed the labs have lost public sentiment, but pushed back that he doesn't see an actual "authoritarian program" on the table right now — what's actually being discussed, he said, looks more like a small number of companies seeking modest antitrust reassurance so they can collaborate on safety without legal risk, not a push to end open source or impose a draconian regime. Prakash disagreed that the ask is modest: citing Roon's prediction that open-weight models will be banned next year, he argued the labs are clearly gesturing toward strong controls on what can be inferred from models — covering bio and cybersecurity risk — which implies GPU surveys, restrictions on fine-tuning and distillation, and controls that even some biosecurity researchers already think go too far given current limits on bio questions to ChatGPT and Claude.
Closing out the show, Nathan said his hope is that any pacing or pause bought by this moment gets used to actually develop the technical solutions — particularly open-source and open-weight models that are powerful and empowering without shipping the most dangerous capabilities — so the ecosystem isn't forced to choose between safety and distributed, decentralized access. He and Prakash then signed off for the day, previewing Tuesday's show: a return visit from Andon Labs and a segment with a married, "famously pronatalist" couple who have started an AI-inspired religion.